Day 2 :
Keynote: Hyper-Pigmentation/Melasma, a rapidly growing skin disorder: Treatments without hydroquinone
Time : 09:30-10:10
Michael Ibbott is an International Educator and consultant. He has been in the Esthetic field over 23 years, and has trained and lectured in the US, Canada, Australia and Korea. His background in Medical Esthetics, Electrology, Shiatsu therapy and other holistic modalities, have given him a unique perspective as to current trends and treatments available to those suffering from Acne, Rosacea, Hyperpigmentation and Melasma. Michael incorporates a logical progression in the understanding and the implementation of treatment protocols and patient care to advance concrete results.
Hyper-Pigmentation (Melasma) an advanced understanding of the causes of hyper pigmentation and what you can do to make a difference, without the side effects of Hydroquinone and A.H.A’s. A breakthrough in natural ingredients: the U.C.E. Complex. How you can lighten and brighten skin without damage.
University Medical Center Schleswig-Holstein
Keynote: Eczema in childhood
Time : 10:10-10:50
Regina Folster-Holst has completed her PhD in 1984 from Christian Albrechts University, Germany. After a Medical Assistant time in a children's clinic for cystic fibrosis and allergy at Amrum, Germany in November 1985 she began her Specialist training for Dermatologists at the Department of Dermatology, Kiel, Germany. In 1992, she was recognized as a Specialist in Dermatology and Allergology. Since 1992 she works as a Senior Physician at the University Medical Center Schleswig-Holstein, Department of Dermatology in Kiel, Germany. Her clinical activity and research priority is primarily in the area of atopic dermatitis, pediatric dermatology and Parasitosis. She has published more than 160 papers in reputed journals. Since May 2016 she is the President of the European Society for Pediatric Dermatology (ESPD).
Eczematous lesions in childhood are very common and mainly related to atopic dermatitis (atopic eczema). However there are many differential diagnoses including other eczematous disorders than atopic dermatitis (AD) as contact dermatitis and seborrheic dermatitis, ichthyoses like ichthyosis vulgaris, parasitoses as scabies, and rare diseases due to immunodeficiency/immune defects including Netherton syndrome and Omenn syndrome, and nutritional deficiency (for example zinc, biotin). Interestingly, there are many different phenotypes of AD, not just age and race-dependent. In this context, the intrinsic and extrinsic form, as well as the classical flexural form and the nummular form have to be mentioned. In many cases the AD can be controlled by avoiding trigger factors and using topical treatment including emollients and anti-inflammatory drugs. However, a small subgroup of patients requires systemic drugs because of recalcitrant disease.
- Track 6. Dermatology: Therapies and Advances
Track 7. Aesthetic Dermatology
University Medical Center Schleswig-Holstein
Peru Dermatology Society
Title: The best neo collagen production: Histological comparison between deep depth chemical peelings: My personal formula Baker & Gordon, Fintzi formula
Time : 11:10-11:30
De Rossi Fattaccioli is the member of American Academy of Dermatology, International Society of Peeling (ISP), Argentina Dermatology Society, Cilad Coligeo Iberolatino Mericano of Dermatology, Peruvian Society of Dermatology. He is the Principal Professor of Dermatology National University of Tacna “Jorge Basadre Grossman” and University of Tacna. He is an ex-President of Peruvian Society of Dermatology.
Chemical peeling is the most ancient procedure to remove and repair the photodamage effects (Ebers Papyrus). The newest with Erbium, Neodimiun YAG Carbon Dioxide (CO2) Laser (ultrapulsed, fractional & others) are being used for the same i.e., remove sun damage elastotic collagen on reticular dermis, atrophic basal-malphigi stratum and hyperkeratosis cornium stratum and production of the best neo Collagen. Phenol deep chemical peelings (Backer-Gordon, Litton, Fintzi and Hetter formulas) have been used and still are being using extensively for facial skin rejuvenation. I introduce a “new” Personal Formulae (1986-2017) which use the heat like penetration factor and Glycerine like buffer and booster at the same time in this formula. These studies have been done to compare the effects of the treatments using histologic views in different periods of time. Biopsies of facial skin treated on pre and retroauricular zone were maked: 24 hours after the application of a new adaptation of the Baker´s formula: DeRossi Fattaccioli`s formulae for deep chemical peeling. Areas near the first biopsies were biopsied after 12 hours, 24 hours, 1 week, 2 weeks, 2 and 3 months after; and 24 hours, 48 hours, 72 hours, 1 week, 1 year and 10 years after application of De Rossi Fattaccioli`s Phenol-Croton. Initial biopsies showed deep chemical peeling Phenol-Croton oil DeRossi Fattacioli`s formulae, have produced a thick zone of new collagen formation, and at 3 months comparatively with others formulae of deep chemical peeling with De Rossi Fattaccioli´s formula show a thicker and wide new collagen zone.
Title: Acne, inflammatory and non inflammatory lesions: Overview and causes on solutions with a medical aesthetic perception
Time : 11:30-11:50
Michael Ibbott is an International Educator and Consultant. He has been in the Esthetic field for over 23 years, and has been trained and lectured in the US, Canada, Australia and Korea. His background in medical esthetics, electrology, Shiatsu therapy and other holistic modalities, have given him a unique perspective as to current trends and treatments available to those suffering from acne, rosacea, hyperpigmentation and melasma. He incorporates a logical progression in the understanding and the implementation of treatment protocols and patient care to advance concrete results.
This presentation focuses on the overview of acne and how to intervene and prevent this skin disorder. The lecture also focuses on: 1. Learning a different approach to treating acne. 2. Learning proper terminology to use with the clients and all the different treatment options that can be implemented in a medical spa setting. 3. Providing clients with optimum results. Lifestyle and prevention methods will be discussed. LED, IPL, new ionotherapy, supplements and all other treatment options will also be covered in this presentation.
Dr Reddy’s Laboratories
Title: Efficacy and Safety of Tretinoin (Microsphere) 0.04% and Clindamycin 1% Combination Gel in Comparison to Tretinoin 0.025% Gel and Clindamycin 1% Gel in the treatment of Moderate to Severe Acne Vulgaris.
Time : 11:50-12:10
Shilpi Dhawan has vast experience in conduct of clinical research in various therapeutic areas . She completed her M.D in Pharmacology and has passion in improving the health and wellbeing of the patients by bringing innovative ideas for increasing patient compliance , adherence to treatment and safety of the patients. She believes in bringing quality and affordable medicines to the patients by doing quality research . She truly believes in generating the quality data and hence trains the sites in protocol and GCP compliance .
Statement of the Problem: Topical retinoids such as Tretinoin are currently used as monotherapy and also in combination with clindamycin for treatment of acne. Although the effectiveness of topical tretinoin is well established, yet the associated skin irritation is a limiting factor in some subjects due to the availability of drug to skin in high concentration in a short period. Novel tretinoin formulation incorporating microsphere technology may improve treatment tolerability, encourage adherence, and contribute to better long-term therapeutic outcomes.
Purpose was to evaluate efficacy, safety and tolerability of novel formulation of Tretinoin (Microsphere) 0.04% and Clindamycin 1% combination gel (T+C) versus Tretinoin 0.025% (T) and Clindamycin 1% (C) in the treatment of Acne vulgaris.
Methodology & Theoretical Orientation: Eligible male and female subjects ≥ 12 years in age with clinical diagnosis of moderate to severe facial acne vulgaris and willing to provide informed consent were randomized in 2:2:1 ratio [Tretinoin (microsphere) 0.04% and Clindamycin 1% combination gel(T+C): Tretinoin 0.025%(T): Clindamycin 1%(C)] and instructed to apply a pea-sized amount of the products to the entire face once daily at bedtime for 12 weeks. Efficacy was evaluated by assessing the reduction in count and severity of acne lesions at each visit. Local tolerability assessments were done at all follow-up visits.
Findings: In our study, a statistically significant reduction in acne lesion count was observed with T+C compared to both T and C showing superior efficacy with combination. An early and a higher response rate in efficacy was observed in T+C arm compared to T and C arms. The combination was well tolerated in the study.
Conclusion & Significance: The combination therapy of Tretinoin with microsphere technology and Clindamycin improved patient satisfaction and adherence to treatment by providing superior efficacy and faster onset of action with better tolerability
Saint Joseph University
Time : 12:10-12:25
Alexandre Malek is a Medical Doctor graduated in 2012, then he did Internal Medicine and now he is doing his last year of Infectious Disease Speciality. He did his study at Saint Joseph University, Faculty of Médicine, Beirut, Lebanon. Currently he is doing one year of Infectious Disease in Paris, France.
An 80 year-old Caucasian man was admitted to the hospital for prolonged fever, weight loss, and general status alteration. He noted a pruritic skin lesion. As past medical history, he had been treated for Hodgkin lymphoma in 1994 and Non Hodgkin lymphoma in 2004. One year ago, he developed Myelodysplastic Syndrome. Thoraco-abdominopelvic CT scan, gastroscopy and colonoscopy were normal. PPD skin test was negative and pancultures were sterile. The physical examination was normal except the presence of multiple, annular, rapidly growing erythematous plaques over the right thigh (Figure 1, 2). Bone marrow aspirate and biopsy revealed acute myeloblastic leukemia (AML). Diagnosis of Erythema Gyratum Repens (EGR) was made on clinical ground and it was secondary to AML. EGR in 80 % of cases is related to underlying malignancies most notably lung cancer. However, EGR in 20 % is associated with nonneoplastic diseases such as pulmonary tuberculosis, autoimmune or connective tissue conditions.
Hemn Ahmed is an enthusiastic board certified Dermatologist. He searches for studying more degrees, which enables him to develop new skills, while strengthening those that he possesses. He started his vocation in Dermatology and Venereology and wants to get more experience and knowledge and enjoys being part of a successful and productive team. He has years of experience in research, evaluation, teaching and administration both in hospital and education institutions.
Statement of the Problem: Due to difficulties in obtaining skin scrapings from some patients and the lack of sensitivity of classical methods in diagnosis of scabies, dermatoscopy is commonly informative.
The Purpose of the Study: To evaluate the diagnostic accuracy of dermatoscopy for diagnosing scabies.
Methodology & Theoretical Orientation: A cross sectional study was carried out at Dermatology Center of Slemnai from 1st June to end of October 2015 on 202 patients with clinical suspicion of scabies. The patients had confirmed diagnosis by clinical diagnosis, dermatoscopy and skin scrapping.
Findings: Studying validity test of dermatoscopy in comparison to confirmed diagnosis revealed that the sensitivity of dermatoscopy was 91.5%, specificity 65%, and +ve predictive value 86%, -ve predictive value 76.5% and accuracy 83.6%. There was a significant association between positive dermatoscopy results and scabies patients with likely or very likely clinical diagnosis (p=<0.001).
Conclusion & Significance: Dermatoscopy is a good screening tool for scabies especially among high risk people.
Recommendations: Encouraging health directorates to start the use of dermatoscopy for screening of scabies, especially among refugees, displaced people and prisoners and the adoption of clinical diagnosis, skin scrapping and dermatoscopy as the diagnostic choice for scabies.
Akdeniz University School of Medicine
Title: The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies
Time : 12:45-13:10
Sevil Alan has received her PhD from Ege University, Turkey during the period of 1993-1999. She completed her Dermatology Residency at the Adana Numune Education and Research Hospital in Adana, Turkey. Currently, she is working as a Dermatologist in Akdeniz University School of Medicine, Turkey. She is an Editorial Board Member of journals like SM Dermatology, Dermatology & Pigmentation Disorders, and International Journal of Clinical Dermatology & Research (IJCDR). She is serving as a Reviewer for journals like JAMA Dermatology, International Research Journal of Public and Environmental Health, International Medical Journal of Sifa University. She has authored many research articles
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15 is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.