Day 1 :
Keynote Forum
Edward Walker
Weber State University, USA
Keynote: Direct determination of dimethicone in skin protection products by FTIR
Time : 10:30-11:30
Biography:
Edward B Walker has received his PhD in Chemistry from Texas Tech University and was a Post-doctoral Scholar in Biochemical Pharmacology at Stanford University. He is a Professor of Chemistry at Weber State University, where he directs the Center of Excellence for Chemical Technology.
Abstract:
Dimethicone is a mixture of fully methylated linear siloxane polymers of various molecular weights. This water-insoluble material provides unique skin protection and lubrication when incorporated into skin care products. At concentrations of 1-30%, the US Food and Drug Administration allow skin protection drug claims as per 21CRF347. Hence, it is important to have dependable methods of analysis for dimethicone in topical skin care products. Since dimethicone is often emulsified in aqueous solutions, current analytical methods required extensive sample preparation such extraction or ashing and subsequent dissolution. We present a new rapid analytical method based upon Fourier transform infrared spectrometry (FTIR), utilizing an Attenuated total reflectance (ATR) cell to determine concentrations of dimethicone directly in aqueous skin lotions and creams, without any sample preparation. This simplified method provides accurate results across a wide range of concentrations while reducing analysis time and minimizing potential sample preparation errors.
Keynote Forum
Thomas Haffner
Heumarkt Clinic, Germany
Keynote: Avoiding operated look and complications by oculoplastic and periorbicular surgeries
Time : 12:00-13:00
Biography:
Thomas Haffner (MD) is a board certified reconstructive, vascular and cosmetic surgeon in Germany. He was trained in the reconstructive-plastic surgery and senology section of the Semmelweis University (Szabolcs Str.) in Budapest. He is specialized also in vascular surgery and worked there many years as department leader in German clinics. Attending educational courses by Prof. E. Biemer had certified in the endoscopic plastic surgery and micro-surgery. He completed cadaver and live Op. courses in the universities of Erlangen, Ulm, Regensburg and resident assistance by Prof. Rettinger in Ulm. In 2000 he established his private clinic for vascular-reconstructive & aesthetic surgery in Cologne, Germany. His primary focus is the breast and facial surgery using minimal invasive and endoscopic methods. He invented the innovative vertical scar free reconstructive 3D mastopexy. He presented a new facelift method the "Temporal Endoscopic Face and Midface Lifting" without facial scars.
Abstract:
Abstract :
Background: Oculoplastic operations are in the top most performed plastic operations worldwide. However, the common way of blepharoplasty doesn’t address hollowing eyes, depletions and skeletonisation around the orbital following natural aging. Neither the blepharoplasty nor periorbital procedures are focused on longevity and aging prevention. Iatrogenic worsening of skeletonisation and hollowing exist by all day routine working. Moreover the aesthetic unit of eyelids, brows, temple, forehead and midface are mostly ignored and not plastic surgically addressed.
Objective: The objective of the study is to demonstrate new trends of extended oculoplastic surgery according to 19 years cosmetic-plastic surgery experience of the author; the meticulous orbicular and endoscopic minimal invasive peri-orbicular procedures being as new standards in the oculoplastic surgery. Aging addresses the whole face; oculoplastic surgeries should be made therefore nor isolated, but considering of the aging of neighboring regions around the eyes.
Methods: New methods such as the fat and muscle augmentation were already presented from many years at conferences through papers such as the muscle and fat augmentation blepharoplasty, the endoscopic minimal invasive brow-temple and midface rejuvenations such as tarsus securing canthopexies. By all these methods disfiguring complications can be prevented and the results be enhanced. These new methods are already new standards today in the oculoplastic surgery and should be known even by dermato-surgeons. The time of common easy blepharoplasty exists no more. The new standards in the oculoplastic surgery such as the muscle and fat augmented upper lid blepharoplasty, the tissue sparing lower lid blepharoplasty, canthoplasty and canthopexy, endoscopic facial rejuvenation are presented and strongly recommended for all actively working oculoplastic surgeons.
Results: Using the new kind of standard procedures in the oculoplastic surgery much better results had been achieved during the past 10 years. An operated look, skeletonisation and disfiguring dimples could be always prevented. All operated patients looks natural, without operated look. The canthopexy with tarsal strip procedure counts as the best way but also the most difficult way in treating scleral show and ectropion. Periorbicular orbicularis shifting and lifting promote much lower lid and cheek position by upper lid blepharoplasty incision. There was no postoperative upper eyelid ptosis and also retreating prolapse of the upper lid doesn´t happen, when an adjuvant direct brow lift or a temple-forehead lift made, when the patients gets botulinum-toxin brow lift regularly. The canthopexy was also used as a preventive procedure against scleral show and ectropion. The scars are very fine and inconspicuous after muscle augmented blepharoplasty.
Conclusions: There are new standards in the oculoplastic and periorbicular and endoscopic facial surgery, which should be known by all operative active orbicular surgeon. The usually performed common ways of upper and even lower lid blepharoplasty are out. Every surgeon must critical proof, whether to perform a skin resection at all by lower lid blepharoplasty, than in any case of lowering of the tarsus, scleral show a iatrogenic damage exist, which had been avoided by no skin excision lower lid blepharoplasty.
- Infectious Disease| Anti Aging | Allergy and Immunology | Sunburn | Melasma | Skin Cancer
Location: Rembrandt 1
Chair
Thomas Haffner
Heumarkt Clinic, Germany
Co-Chair
Edward Walker
Weber State University, USA
Session Introduction
Takuya Kajisa
Futakotamagawa Cosmetic Surgery Clinic, Japan
Title: Rejuvenation of facial sagging and wrinkles: ‘Balance theory’ – a novel concept for the restoration of the support of the skin
Biography:
Takuya Kajisa has completed his PhD from Juntendo University and postdoctoral work at the same facility. Currently, he is Director of Futakotamagawa Cosmetic Surgery Clinic and Non-Full-time-Assistant Professor at Juntendo University.
Abstract:
Sagging and wrinkles are serious problems for the people who want to look young and attractive. Treatments for facial rejuvenation thus far include laser, filler injection, thread lifts, PRP, and facelift surgery, etc. But none of these treatments can bring in long lasting result by itself. We have been using growth factor injection for more than 10 years for treating sagging and wrinkles. As the main component of the skin is collagen, so the restoration of the support provides evident results. Assuming several subunits of the face, we found that balance of the volume of injective fluid between subunits is important for ideal results. And for better results, we used retinoic acid and hydroquinone. These recover the fine wrinkles, spots and textures of epidermis, the most superficial layer of the skin. We believe that both collagen restoration, which occurs in deeper layer, and epidermal restoration are ideal combination for facial rejuvenation. With either of these treatments cannot provide satisfactory result, thus the ‘balance’ of the restoration of superficial layer and deep layer is demanded. After single treatment, the effect of the treatment lasts for years, so patients don’t need repeated treatments. After treating just one time, patients only have to take care of ultraviolet rays, foods, sleep, and so on. Such habits are also beneficial for their health. So we believe that the ‘balance’ of restored skin which is located outside and maintaining inner health is important.
Biography:
Thomas Haffner M. D. is a board certified reconstructive, vascular and cosmetic surgeon in Germany. He was trained in the reconstructive-plastic surgery and senology section of the Semmelweis University (Szabolcs Str. ) in Budapest . He is specialised also in vascular surgery and worked there many years as department leader in german clinics. Attending educational courses by Prof. E. Biemer had certified in the endoscopic plastic surgery and micro-surgery. He completed cadaver and live Op. courses in the universities of Erlangen, Ulm, Regensburg and resident assistance by Prof. Rettinger in Ulm. In 2000 he established his private clinic for vascular-reconstructive & aesthetic surgery in Cologne, Germany. His primary focus is the breast and facial surgery using minimal invasive and endoscopic methods. He invented the innovative vertical scar free reconstructive 3D mastopexy. He presented a new facelift method the "Temporal Endoscopic Face and Midface Lifting" without facial scars.
Abstract:
Background: An oculoplastic surgeon needs to be aware of basic processes of aging around the orbita, such as tissue loss and depletions, when he or she performs tissue removing operations around the orbita.
Objectives: The authors present their concept and 10 years’ experience with the orbicularis muscle augmenting blepharoplasty without any resection of the orbicularis muscle.
Method: The first step of the acces into the upper eyelid are made very meticulously avoiding any block resection of skin and orbicular muscle – preveting by this way also damaging the levator aponeurosis and preventing iatrogenic postoperative eyelid ptosis. Fibers of the orbicular muscle are not to be resected when accessing of the prolapsed fat pockets. Gentle spreading of the muscle fibers is the right way, to save the muscles and their smallest motoric nerves at the muscle belly. Shrinking of the orbicularis by heating, coagulation whith laser or electric current is obsolete. Almost no touch handle of the orbicularis necessary, than a proper imbrication, plication are our the last steps of blepharoplasty, whith which a muscular filling of existing or in the future arising depletions and a youthfully looking orbita reached. More than 330 blepharoplasty cases in between 2006-2016 were analyzed in this retrospectiv study of the orbicular muscle augmentation blepharoplasty. .
Results: The evaluation of our patient´s collective reveals, that the goal of this special procedure such as youthfully look, refreshing effect without hollowing of the orbita was achieved. The natural aging process wasn´t reinforced but prevented by the muscle augmentation. In contrast the postoperative photographs showed a little bit hollowing of the orbita and disadvantageous deepening of the eyelid fissure in those few cases, when preserving of the muscle fibers was not meticulously performed. The improvement of the freshness of the orbita was long-lasting and resulted in much younger looking and freshness of the entire face. No major complications and no wound infections occurred. Minor complications such as irritation of the conjunctiva, slight conjunctivitis whith tear drops were noticed in 6 % of the cases and healed by eye drops within 5-7 days completely. We ca state a very diminished bruising and swelling. We think, that it is of the meticulous bipolar coagulation avoiding mass coagulation and bleeding also.
Conclusions: Saving of the orbicularis muscle is an important new perspective in the upper eyelid surgery. Preventing iatrogenic depletions after a procedure and should be the most important goal of any oculoplastic surgeon, since aging will cause hollowing and depletions during life in any case. A compensation of depletions by fat and micro fat grafting is a very good strategy and should be an additional step in optimizing of results after blepharoplasty. However prevention of iatrogenic depletions and hollowing must be the main goal. The usual practice of simple blepharoplasty, whith block resection of skin- and eyelid muscles and fat and uncontrolled deep incisions reaching to the levator aponeurosis should be reconsidered. Skeletonisation of the orbita is an natural the aging process. This disadvantegous natural aging process musn´t be worsened by the old type of tissue damaging-resecting blepharoplasty. Postoperative iatrogenic ptosis, skeletonisation of the orbita and unnatural deepening of the supratarsal fissure, and an “operated look” are the consequences of an old type muscle-resection blepharoplasty. An optmised oculoplastic procedure should prevent iatrogenic tissue loss, iatrogenic injury of the muscles and levator sheet and should save the natural muscles of the eyelied.
Samaa Samir Kamar
Cairo University, Egypt
Title: wound healing in type-I diabetic rat: Histological and immunohistochemical studies
Biography:
Samaa Samir Kamar has completed his PhD from Faculty of Medicine, Cairo University, Egypt. She has published 10 papers in reputed journals. She has skills in Cell Biology, Histological and Immunohistochemical studies.
Abstract:
Management of diabetic wounds remains a major challenge in the medical field, mostly due to incompetent outcomes of treatments. Curcumin has been documented as anti-inflammatory, antioxidant, antimicrobial and antineoplastic agent in addition to wound healing activities. However, its poor aqueous solubility and impaired skin permeation handicap its topical pharmaceutical usage. Hydrogel loaded curcumin nanoparticle (Cur-NP/HG) could overcome this pitfall and enable extended topical delivery of curcumin. Rat model of diabetes mellitus (DM) type I was induced using single injection of 70 mg/kg streptozotocin (STZ) followed by full thickness skin wound. Rats were divided into four groups. GpI: control non-diabetic, GpII: diabetic non-treated, GpIII: diabetic treated with topical curcumin hydrogel (Cur/HG) and GpIV: diabetic treated with topical Cur-NP/HG. Histological assessment of epidermal regeneration, dermo-epidermal junction, leukocyte infiltration and collagen deposition, in addition to immunohisto-chemical staining for vascular endothelial growth factor (VEGF) and aquaporin-3 (AQP3) were performed. Diabetic rat possessed impaired wound closure, persistence of inflammation and decreased collagen deposition as compared to non-diabetic control. Application of Cur/HG induced partial improvement of the healing process in diabetic rats. Cur-NP/HG treatment provoked obvious improvement of the healing process with complete re-epithelization, intact dermo-epidermal junction, reorganization of the dermis with significantly increased collagen deposition and VEGF and AQP3 expression. These results illustrated that, Cur-NP/HG have effectively improved the healing process in diabetic skin wound with substantial differences in the wound healing kinetics compared to wounds that received Cur/HG.
Yoav Gronovich
Shaare-Zedek Medical Center, Israel
Title: Improvement of facial scars using autologous fat graft and 1540 nm nonablative erbium laser
Biography:
Yoav Gronovichis is the head of the Plastic Surgery Department at the Shaare Zedek Medical Center in Jerusalem. He has received his Medical degree from the Hebrew University in Jerusalem, and has completed his Residency in Plastic Surgery at the Shaare Zedek Medical Center in Jerusalem. He has been actively involved in research, including more than 20 publications, oral presentations and abstracts. His interests include aesthetic and reconstructive surgery of the face, breast and body, and advanced treatments of scars.
Abstract:
Background: Facial scars are a devastating problem both aesthetic and functional. Many treatments have been proposed for improvement of scars. Among the advanced treatments are the use of non-ablative laser, which facilitate the synthesis and deposition of collagen in the dermis. Other advanced treatments include fat grafting. This method helps to reshape the scar by volumetric effect of the fat cells, and improve its contour by the adipose derived stem cells that accompany the fat transfer.
Results: In all of the cases, the treatment was uneventful with no side effects. The scars were improved both in texture and appearance. Patient satisfaction was high in all of the cases.
Golnoush Kouhihabibidehkordi
Shahrekord University of Medical Sciences, Iran
Title: Skin wound and white tea
Biography:
Golnoush Kouhihabibidehkordi is a General Physician and Researcher from Iran. She has graduated from Shahrekord University of Medical Sciences, Iran, in 2013. Since then, she has been working as a General Physician in hospitals and clinics, and as a Researcher in research center of Shahrekord University of Medical Sciences, Iran.
Abstract:
Introduction: Skin wound is a cut or tear happen to skin which protects our body from foreign factors and dehydration. By considering the positive effect of green tea on the surgical and burn wounds and similarities between green tea and white tea and the more antioxidant properties of white tea in comparison with green tea, this study is designed to evaluate the effect of white tea extract on healing process of excisional skin wounds in rats.
Methodology & Theoretical Orientation: For this experiment, 105 healthy male Wistar rats (200-250 g) were randomly divided into two types: Ointment (Eucerin) and gel. Each type was divided into three groups containing 21 rats: Control group ( which is the same in both types), vehicle (Eucerin)-treated group, white tea 5% ointment (Eucerin) treated group, vehicle (gel)-treated group, white tea 5% gel treated group. On the day 0, excisional skin wounds were created. Treatment was begun at the day one and repeated every day at the same time until day 15. Pathologic samples were taken at days four, seven and 15 for histopathological examinations. At the end, by the use of SPSS software and Kruskal-Wallis analysis of variance, collected data was analyzed and P value <0.05 was considered as significant.
Findings: Results of this study shows that in day seven, reepithelialization and granulation tissue of control group is significantly (p<0.05) more than white tea treated group and the inflammation of white tea treated group is significantly (p<0.05) more than control group.
Conclusion: In this study, 5% white tea extract could not help the healing process of the skin wounds in rats.
Golnoush Kouhihabibidehkordi
Shahrekord University of Medical Sciences, Iran
Title: Skin wound and white tea
Biography:
Golnoush Kouhihabibidehkordi is a General Physician and Researcher from Iran. She has graduated from Shahrekord University of Medical Sciences, Iran, in 2013. Since then, she has been working as a General Physician in hospitals and clinics, and as a Researcher in research center of Shahrekord University of Medical Sciences, Iran.
Abstract:
Introduction: Skin wound is a cut or tear happen to skin which protects our body from foreign factors and dehydration. By considering the positive effect of green tea on the surgical and burn wounds and similarities between green tea and white tea and the more antioxidant properties of white tea in comparison with green tea, this study is designed to evaluate the effect of white tea extract on healing process of excisional skin wounds in rats.
Methodology & Theoretical Orientation: For this experiment, 105 healthy male Wistar rats (200-250 g) were randomly divided into two types: Ointment (Eucerin) and gel. Each type was divided into three groups containing 21 rats: Control group ( which is the same in both types), vehicle (Eucerin)-treated group, white tea 5% ointment (Eucerin) treated group, vehicle (gel)-treated group, white tea 5% gel treated group. On the day 0, excisional skin wounds were created. Treatment was begun at the day one and repeated every day at the same time until day 15. Pathologic samples were taken at days four, seven and 15 for histopathological examinations. At the end, by the use of SPSS software and Kruskal-Wallis analysis of variance, collected data was analyzed and P value <0.05 was considered as significant.
Findings: Results of this study shows that in day seven, reepithelialization and granulation tissue of control group is significantly (p<0.05) more than white tea treated group and the inflammation of white tea treated group is significantly (p<0.05) more than control group.
Conclusion: In this study, 5% white tea extract could not help the healing process of the skin wounds in rats.
Murada Abobaker Muttardi
University of Benghazi, Libya
Title: A comparative study of clinical response to topical minoxidil and topical corticosteroids in adult Libyan patients with alopecia areata in Jumhouria Hospital in Benghazi
Time : 16:30- 17:00
Biography:
Murada Al Muttardi, University of Benghazi, Libya
Abstract:
In clinical study of alopecia areata in patient including 50 cases presented to Jumhurya Hospital Benghazi – Libya in period from January 2012 to May 2012, showed a preponderance in female (M:F 1:1.3) and the majority of patients (74%) were below 40 years of age. Family history of alopecia areata was present in 18%. The common patterns of alopecia areata observed in our study were: Patchy seen in 86%, majority (80%) of patients presented with (1-3) patches, atopy was recorded in (82%) of cases, associated disease in (4%). Nail changes were noted in 42% of cases topical monetasonefuroate 0.1% showed significant better response compared to minoxidil 0.2% in the treatment of patchy AA. Side effects itchy, redness and headache were observed in three patients, who treated with minoxidil 0.2% and there is no side effects observed in patients who treated with topical monetasonefuroate 0.1%. Minoxidil has a significant stimulatory effect on hair growth in AA and it can be used as an adjuvant in the treatment of AA with topical monetasonefuroate 0.1%. The combination treatment may yield a better clinical response than either of the agents used singly as the mechanism of action of both agents are totally different.
Munirah T Aljaser
Al-Farwaniya Hospital, Kuwait
Title: The treatment and the prevention of complications in a case of pustular psoriasis of pregnancy (impetigo herpetiformis)
Biography:
Munirah T Aljaser has received her Bachelor of Medical Sciences (BMed Sc) and Bachelor of Medicine and Surgery (BM, BCh) from Kuwait University. She is currently working as a Physician at Al-Farwaniya Hospital, Dermatology Department.
Abstract:
Pustular psoriasis of pregnancy (PPP) is a rare dermatological disease associated with potentially life-threatening maternal and fetal outcomes. We report a case of a 25-year-old primigravida Arabian woman diagnosed with PPP at 36 weeks of gestation, presenting initially as generalized erythematous plaques. Early recognition and treatment with prednisolone, induction of labor, and later with the addition of cyclosporine, we were able to avoid the complications related to PPP. Given the prognosis of untreated PPP, it is imperative to standardize the method of diagnosing and treating the disease to ensure the best possible outcomes for both the mother and the fetus.
Warkaa Mahmood Ali Al-Wattar
Mustansiriya University, Iraq
Title: Effect of 790-805 nm diode laser therapy on mast cell in cutaneous wound healing in mice
Biography:
Warkaa Mahmood Ali Al-Wattar has completed her PhD in Oral histology, in 2013. She is the Head of Oral Pathology Department from 2016-2017, a Member in IDA, Editorial Board Member in five medical and dental Journals. She has published one book and 14 research and editorials. She has reviewed about 12 research in Dentistry, and responsible for Oral Pathology lab in Mustansiriyah University.
Abstract:
Background & Objective: The use of low level laser therapy (LLLT) has been increased now a days to accelerate healing of soft tissue injuries because of some biostimulatory effects. The aim of this study is to investigate the effect of 790-805 nm diode laser on the inflammatory effect of mast cells during wound healing in rodents.
Materials & Methods: A cut wound (1.5 cm) was done on the cheek of 40 albino mice. Twenty of them exposed to LLLT (360 J/cm 2) at 790-805 nm immediately post wounding procedure. The animals were scarified and the wound area was prepared and stained with toluidine blue.
Results: Mean mast cell count of 10.2 on the first day of control group while in laser group 8.4. The control and laser group showed a gradual inclination in the mean value to be return to increase at the day 14 of the experiment. There was a significant difference (P<0.05) in the control group on the first day. While the significant difference (P≤0.05) was in the day seventh. Pearson correlation showed a significant correlation (P≤0.01) between the control group at the day one and the laser group on the day seven. While, there was a significant correlation (P≤0.05) between the control group at the day 14 and laser group on the day one.
Conclusions: LLLT may induce an anti-inflammatory effect on wound healing process by its inhibitory action on mast cells; while it may have a biostimulatory effect on the proliferation of mast cells in the proliferative phase of wound healing, which indirectly affects fibrous tissue regeneration in the subcutaneous area.
Asmaa Gaber Abdou
Menoufi a University, Egypt
Title: Immunolocalization of MUC1 in chronic plaque psoriasis
Biography:
Asmaa Gaber Abdou is a Professor of Pathology, Faculty of Medicine, Menoufia University, Egypt. She is an editorial member in several international journals such as World Journal of Methodology. Her area of expertise is Dermatopathology and Cytopathology. She acts as a Reviewer at Egyptian Scientific Pathology Committee for Assistant Professors and Professors. Number of publications is 88 including 78 articles indexed in PubMed/Medline in international journals. Total citations are 739 and H index is 13 according to Google Scholar and 10 according to Scopus. Promotion, she got encouraging prize for young researchers, 2011 provided by Menoufia University and Egyptian encouraging prize offered by Academic Scientific Research and Technology (ASRT), in 2015.
Abstract:
State of the Problem: Psoriasis is a chronic skin inflammatory disease with immunological, hyperproliferative and angiogenic dysfunction. MUC1 is a molecular sensor and signal transduction that responds to external stimuli generating cellular responses, which include cell proliferation, growth, differentiation, migration, invasion, survival and secretion of growth factors and cytokines. The purpose of the present study is to evaluate the possible role of MUC1 in the pathogenesis of psoriasis.
Methodology & Theoretical Orientation: Immunohistochemical localization of MUC1 in involved and uninvolved psoriatic skin compared to normal skin was performed, in addition of correlating MUC1 expression with the clinical and pathological parameters of psoriasis. The current study investigated 30 patients with psoriasis and 10 controls. MUC1 was expressed in epidermis in 30% of normal skin compared to 20% of uninvolved epidermis and 63.3% of involved epidermis of psoriatic skin. MUC1 was seen staining endothelial cells of capillaries and inflammatory cells in dermis in 10% of normal skin, 0% of uninvolved psoriasis and 83.3% of involved psoriasis. Dermal expression of MUC1 in psoriasis was associated with mild to moderate degrees of epidermal acanthosis (p=0.027). Intense MUC1 expression by psoriatic epidermis was associated with short disease duration (p=0.044).
Conclusion & Significance: The upregulation of MUC1 in involved psoriatic lesion compared to uninvolved and normal skin may suggest MUC1 role in pathogenesis of psoriasis especially early stages. MUC1 may be responsible for less severity of psoriasis in old aged patients. Using of MUC1 target therapy could be beneficial in treatment of psoriasis.