Shricharith Shetty
Kasturba Medical College
India
Title: Autologous platelet rich fibrin therapy in chronic leg ulcers
Biography
Biography: Shricharith Shetty
Abstract
Background & Objectives: Leg ulcers are chronic wounds with varied causes and great medical impact. Management is complex and is associated with high costs for both patients and public health services, especially in low income-countries. In this study, we investigate the effect of autologous platelet rich fibrin (PRF) on healing of chronic non healing ulcers. Methods: A total of 37 patients with chronic non healing ulcers attending dermatology outpatient clinic were included in study population. A total of 43 ulcers were treated with PRF dressings. The patients were followed up on weekly basis for three months. Swab cultures were taken upon initial visit and then on weekly basis. The judgment criteria’s were the relative regression of the wound surface area and relative reduction of sloughy tissue. Results: Mean healing time was 35±4 days. 76.5% of ulcer became sterile during first week. Conclusion: PRF is simple and an effective treatment for chronic non healing ulcers leading to significant reduction in the time of healing. This study also strongly supports antibacterial effect of platelet rich products. Being autologous, PRF is safe and can be prepared without any sophisticated instruments with minimal cost and hence reducing the economic burden. Limitations: Diversity in the sites and causes of ulcers. Analysis to validate that the composition of PRF did not differ from case to case was not carried out.