Asmaa Gaber Abdou
Menoufi a University, Egypt
Title: Immunolocalization of MUC1 in chronic plaque psoriasis
Biography
Biography: Asmaa Gaber Abdou
Abstract
State of the Problem: Psoriasis is a chronic skin inflammatory disease with immunological, hyperproliferative and angiogenic dysfunction. MUC1 is a molecular sensor and signal transduction that responds to external stimuli generating cellular responses, which include cell proliferation, growth, differentiation, migration, invasion, survival and secretion of growth factors and cytokines. The purpose of the present study is to evaluate the possible role of MUC1 in the pathogenesis of psoriasis.
Methodology & Theoretical Orientation: Immunohistochemical localization of MUC1 in involved and uninvolved psoriatic skin compared to normal skin was performed, in addition of correlating MUC1 expression with the clinical and pathological parameters of psoriasis. The current study investigated 30 patients with psoriasis and 10 controls. MUC1 was expressed in epidermis in 30% of normal skin compared to 20% of uninvolved epidermis and 63.3% of involved epidermis of psoriatic skin. MUC1 was seen staining endothelial cells of capillaries and inflammatory cells in dermis in 10% of normal skin, 0% of uninvolved psoriasis and 83.3% of involved psoriasis. Dermal expression of MUC1 in psoriasis was associated with mild to moderate degrees of epidermal acanthosis (p=0.027). Intense MUC1 expression by psoriatic epidermis was associated with short disease duration (p=0.044).
Conclusion & Significance: The upregulation of MUC1 in involved psoriatic lesion compared to uninvolved and normal skin may suggest MUC1 role in pathogenesis of psoriasis especially early stages. MUC1 may be responsible for less severity of psoriasis in old aged patients. Using of MUC1 target therapy could be beneficial in treatment of psoriasis.