6^th International Conference on Clinical and Experimental Dermatology May 04-06, 2016 Chicago,Illinois, USA

Malihe-Sadat Poormasjedi-Meibod has completed her PhD at University of British Columbia and currently working as a Postdoctoral research fellow at International Collaboration on Repair Discoveries. She has published 9 papers in reputed journals and has been serving as the President of the Canadian Biomaterial Society BC student chapter since 2012.

More than 15 million patients develop pathological scarring each year following elective operations, surgical procedures and deep dermal trauma. These scars, that cause major functional, cosmetic, psychological and social consequences for the patients, impose a significant financial burden on health care systems. The current treatment modalities for these pathological conditions vary from topical application and intralesional injection of anti-scarring agents to surgical revisions and radiotherapy. The limited efficacy of this therapeutics for prevention of scar formation raised a great need for innovation within the wound care industry. Recently Kynurenine (Kyn), a tryptophan metabolite has been identified as a potent anti-fibrotic agent. Kyn prevents scar formation by enhancing the expression of extracellular matrix (ECM) degrading enzymes, matrix metalloproteinases (MMPs) and suppressing the expression of collagen. Although daily topical application of Kyn-cream improved the wound-healing outcome in animal models, this method of drug delivery is not clinically practical in situations where dressings need to be kept on for 3-5 days. In this study, we report the fabrication of nano-fibrous wound dressing for slow and controlled release of Kyn or its metabolites. In addition, we evaluated the anti-scarring efficacy of these dressings in vitro and in open wounds in animal models. The findings of this study demonstrated that development of an anti-fibrogenic dressing is feasible and as such its application would overcome the difficulties associated with development of hypertrophic scarring frequently seen in millions of patients worldwide.

John Zade was graduated with an Honorary Bachelors of Science from Binghamton University and he is currently pursuing his Medical degree. He is a Research Fellow at Columbia University and Mount Sinai in the Department of Dermatology. He is the author of two pending medical patents and has co-authored published papers in reputed journals.

The injection of soft tissue augmentation products or fillers is now a commonplace aesthetic procedure. When the American Society for Aesthetic Plastic Surgery (ASAPS) conducted a survey in 2014 of the most common non-surgical procedures in the United States, it found the injection of hyaluronic acid (HA) fillers was the second only to botulinum toxin injections. Hyaluronic acids have a superior safety profile when compared with other soft tissue augmentation products because they exhibit minimal tissue reactivity while being reversible with commercially available hyaluronidase preparations. As such, the storage of HA fillers has come under scrutiny in recent years and the use of these products past their expiration date has come to light. While not uncommon, reuse of HA fillers after opening or past their expiration date is not recommended by manufacturers and has led to controversy since the science behind these practices is infrequently studied. In our study, we cultured 17 used and unused HA fillers from syringes that were stored in recommended conditions but had passed their expiration dates (range of 9 months to 3 years). Analysis did not reveal a single case of bacterial growth in any of our samples. However, more studies are needed before conclusive statements can be drawn from these data. In addition, samples were not analyzed for physical degradation that may reduce the filler’s in vivo effectiveness.

Michael Isaacs graduated with a Bachelor of Science from the University of Notre Dame and will receive his Doctor of Medicine Degree in May 2016 from the Indiana University School of Medicine (IUSM). He is the President of the Dermatology Student Interst Group at Indiana (IUSM), in addition the leading the History of Medicine Student Interest Group. He has published and presented more than 10 projects in dermatology and medicine in both clinical and bench research. Outside of medicine, Mr. Isaacs enjoys Notre Dame football, playing guitar, and weighlifting.

The “Lucky Luke” sign describes a bilateral holster-shaped eczematous rash on the posterolateral hips and upper buttocks in infants secondary to an allergic contact dermatitis to rubber or dyes commonly found in diapers. However, the characteristic “Lucky Luke” distribution has never been previously described in adults. Here we present the first reported adult case of the “Lucky Luke” sign resulting from a contact dermatitis secondary to a clothing label. As this case highlights, the distribution of an eruption plays an important role in identifying the possible etiology at initial consultation. Predominant involvement of convex skin surfaces in combination with sparing of the concave surfaces provides clinical evidence suggestive of clothing contact dermatitis as is demonstrated in this patient. Furthermore, as this reports demonstrates, an initial negative patch test should not divert a practitioner away from diagnosing contact dermatitis, but instead should lead a clinician to consider further patch testing if the overall clinical picture is still strongly suggestive of this diagnosis.

Tetyana Svyatenko has completed her PhD at the age of 27 years from Bogomolets National Medical University (Kiev, Ukraine), has completed her Professor at the age 35 from Bogomolets National Medical University (Kiev, Ukraine). She is the director of Center Dermatology and Cosmetology of Professor Sviatenko. She is professor of Dermatovenerology department of Dniepropetrovsk state Medical Academy, Ukraine. She has published more than 300 papers in scientific journals and has been serving as an editorial board member of repute. Participant and speaker at more than 200 scientific congresses and symposia in Ukraine and abroad. Founded a school for atopic patients in Dnepropetrovsk region.

Monilethrix - of genetically deterministic pathology hair, manifested an anomaly hair of the rod, accompanied by it's fragility caused by the structural weakness of hair fiber in hair keratins. The most common autosomal-dominant type of inheritance (the mutations in keratins number 81, 83, 86). We observed the girls 3-years old with complaints on the hair loss, fragility of hair, inability to grow hair the desired length. The first signs of the disease showed up at the age of 1 - 2 months. The child was fourth by count in the family. Family history is not burdened, in both parents and relatives the violation of hair is not have been observed. Data about the disease in distant relatives are unknown. The child is somatically healthy. The hair on the head short, with the different length( 0,5-2 cm), dry, fragile, uneven painted on the back of the head and back side of the neck. Can be seen small nodules hyperkeratosis. When microscopy on the rods hair determined by the spindle - shaped thickening and waist. Recommended: products with a high iron content, vitamins A and E, gelatin, lotion with 5% urea, gentle care of the hairy part of the head with the exception of slip and trauma. Conclusion: monilethrix has a hereditary nature of the long- and unpredictable course. Is important advocacy with parents in relation to the rules of care of hairy part of the head and smoothing of adverse effect of cosmetic defect on the psyche of the child.

Nari-Kim has completed her M.S., Departure of Dermatology at the age of 26 years from Chungnam National University School of Medicine. She has worked at COSMAX cosmetic company with Loreal group. She is the Research associate of Research and Development Team, PohangTchnopark.

Exposure to ultraviolet (UV) light can cause skin photoaging, which is associated with upregulation of matrix metalloproteinases (MMPs) and downregulation of collagen synthesis. It has been reported that MMPs, especially MMP-1, MMP-3 and MMP-9, decrease the elasticity of the dermis by degrading collagen. In this study, we assessed the effects of Polygonum viscoferum extract (PVE) on photoaging and investigated its mechanism of action in human skin fibroblast (Hs68) cells after UVB exposure using real time polymerase chain reaction, Western blot analysis and enzymatic activity assays. PVE exhibited an antioxidant activity and inhibited elastase activities in vitro. We also found that PVE inhibited UVB-induced cytotoxicity, MMP-1 production and expression of MMP-1, 3 and 9 mRNA in Hs68 cells. In addition, PVE decreased UVB-induced MMP-2 activity and MMP-2 mRNA expression. These effects are linked to the upregulation and downregulation of Smad3 and Smad7, respectively. Another effect of UV irradiation is to stimulate activator protein 1 (AP-1) activity via overexpression of c-Jun/c-Fos, which in turn, upregulates MMP-1, 3 and 9. In this study, we found that PVE suppressed UV-induced c-Jun and c-Fos mRNA expression. Taken together, these results demonstrate that PVE regulates UVB-induced expression of MMPs by inhibiting AP-1 activity and restoring impaired Smad signaling, suggesting that PVE may be useful as an effective anti-photoaging agent.

Tirsit Retta Woldeyohanes has completed her MD from Jimma University and dermato-venereology specialty certificate from Addis Ababa University. She was outstanding and the chief resident in AAU being responsible for 37 residents. She is also a member of EDVS and CPD working committee. She has 4 publications in reputed journals and has been serving as a reviewer for JBI systematic review.

Pseudoxanthoma elasticum (PXE) is a hereditary disorder affecting the elastic fibers in the connective tissue of the skin, eyes and cardiovascular system. Calcinosis Cutis is cutaneous calcification resulting from deposits of calcium and phosphorus salts in the skin. We report a 45 year old female Ethiopian patient who presented with multiple hyperkeratotic plaque lesions around the abdomen with oozing of chalk-like material diagnosed as pseudo-xanthoma elasticum (PXE) with dystrophic calcification after histopathologic evaluation.