15^th International Conference on Clinical and Experimental Dermatology September 28-29, 2018 San Antonio, Texas, USA

Kaur A has completed her MBBS at the age of 24 years from Government Medical College And Hospital, Chandigarh (UT), INDIA. She is currently pursuing her post graduation junior residency i.e. MD dermatology, venereology, and leprosy from Government Medical College And Hospital, Chandigarh (UT), INDIA. She has 2 case reports that are under publications. She has presented around 5 posters and 2 oral presentations in different national conferences.

The incidence of cutaneous tuberculosis is 0.1%. Lupus vulgaris (LV) is the most common, post-primary; highly destructive form of cutaneous tuberculosis in a patient with intact immunity. Various forms of LV seen are the plaque, ulcerative, hypertrophic, vegetative, tumor, papular, and nodular forms. rnObjective: To report a rare case of multifocal LV-plaque and hypertrophic variant in the same patient. Case report: 11-year-old male presented with reddish-violet coloured scaly plaques on the left side of the face for the past 3 years and erythematous hyperkeratotic lesion over right elbow which appeared 6 months later. There was no history of the similar lesion in the family. No past history of pulmonary TB inpatient or family. Investigations- Mantoux test was positive (17mm x 20mm). Histopathology showed multiple granulomas in the dermis containing Langhans giant cells, epithelioid cells, lymphocytes and plasma cells with no caseation in the dermis. No acid-fast bacilli on zeil Neilson staining. Cultures were negative. Chest X-ray was normal. Treatment- the lesions resolved with the antitubercular treatment (Rifampicin, isoniazid, ethambutol, and pyrazinamide) which was continued for 6 months. Conclusion- As LV is a paucibacillary form of tuberculosis, demonstration of the organism (Mycobacterium Tuberculosis) is not possible. Considering the clinical scenario and histopathology, due to high index of suspicion in an endemic country like India, antitubercular treatment should be started and continued if the lesions respond.

Inga Guogiene is a PhD candidate working as a plastic and reconstructive surgeon at the Lithuanian University of Health Sciences Kaunas Clinics. She has completed her specialty training in 2013 at the Hospital of Lithuanian University of Health Sciences Kauno Klinikos Deparment of Plastic and Reconstructive Surgery and underwent fellowship training at the The Université Hospital of Lyon (Lyon, France (2012)) and University Hospital of Bordeaux (Bordeaux, France (2012-2013)). 2013 – 2 month laser practice surgery at doctor‘s Dominique Boineau centre de medecine esthetique in Bordeaux, Bordeaux, France;

A single-center randomized, controlled, parallel-group clinical trial was conducted to compare donor and recipient wound healing after different thickness split-skin grafts (SSG) were used to cover traumatic or postoperative skin defects. We included 84 patients between the age of 18 and 70, with defects that were less than 20 % TBSA and who had no relevant comorbidity or therapy applied that may have delayed wound healing (e.g. uncontrolled diabetes, radiation therapy, etc.). Patients were randomly allocated to three different graft thickness groups: 0.2 mm, 0.3 mm and 0.4 mm. STSG was performed using electric dermatome and the all of the grafts were harvested from anterior portion of upper thigh. Postoperatively on days 3, 7, 14 and 28 days we evaluated pain, epithelialization, secretion, erythema, edema, local temperature and fluctuation. All of the parameters were evaluated on a scale from 0 to 5. rnWe found that the comparison groups were homongenous by age, gender and wound size in cm2. Most of the primary defects were found in lower extremities. Majority of the skin decects were caused by thermal burns (60%), whereas others were post-traumatic (30%) and postoperative (10%). The only significant difference between groups was in epithelialization and pain (p < 0.05). The fastest donor and recipient wound epithelialization was identified in 0.2mm STSG group, where donor wounds in 28 patients (93.3%) and recipient wounds in 17 patients (60.7%) were fully epithelialized in 4 weeks. Pain perception was the highest in recipient wound when 0.2mm STSG was used, whereas donor wound pain perception was the highest in 0.4mm STSG group. rnWe concluded that thickness of the skin graft is a significant factor affecting recipient wound healing parameters. It is necessary to evaluate healing of the donor wound, as well as late outcomes, such as scarring, pigmentation, and esthetic results of skin grafting with different thickness grafts. Hence this study project is continued with the aim to perform a follow up analysis of the patient outcomes 6 months and 12 months after the procedure.

Ankita Tuknayat is pursuing her post graduate residency in Dermatology in Government Medical College and Hospital , Chandigarh, India. She has 2 international publications namely Cyclophosphamide Induced Hearing loss – Reversibility and Preventive strategies in American Journal of Therapeutics and Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation in International Journal of Trichology.rnShe has presented various papers as Speaker and multiple posters in various dermatology conferences across India. She has also won a second award in a poster presentation in a national conference on Dermatophytosis conducted in Post Graduate Institute of Medical Education and Research in 2017. She is an avid participant in various activities of Chandigarh Dermatology Society.

INTRODUCTIONrnCases of familial dermatophytosis are increasing at an alarming rate. The present study aims to investigate the possible contributing factors which may be responsible for this.rnrnMATERIALS AND METHODSrnRetrospective questionnaire based study. Patients with dermatophytosis with atleast one more member of the family affected were included. A performa was filled & history was taken about the risk factors like first member affected, number of members affected , site of infection in the index case, site of infection of all other subsequent members affected, soap/detergent used to bathe/wash, use of over the counter drugs, sharing of clothes/towels, use of antiseptic soaps, washing all the clothes in the same vessel etc. rnrnRESULTSrnOut of the 113 families, 20 families all of its members were affected. Cruris was the initial site of infection in maximum number of patients. Spouse of the affected patient was always affected. All families gave history of using an antiseptic soap. All gave history of using over the counter creams. Washing all the clothes together was a common factor. All families had a single bathroom & used the same soap. rnrnDISCUSSIONrnThe most important is use of antiseptic soaps which kill the normal flora of the skin , making it easy for the microorganisms to break the barrier. Use of over the counter creams could be responsible for decreasing the inflammatory reaction and leading to persistence. Though risk factors have not been extensively studied but these possible risk factors may be responsible for the increasing epidemic.

AFAF KHOUNA has completed her medical studies at the age of 24 years from Mohammed first University, from faculty of Medicine and Pharmacy of Oujda, Morocco. In November 2016rnshe was admitted to the residency contest at the Faculty of Medicine and Pharmacy of Oujda:rnspecialty \"Dermatology, venereology and allergology\" Inter University Diploma in \"Pediatric Dermatology\": obtained on 02/07/18 in Nantes University, France . She participate in the care of patients in the dermatology department, and research activities . She has published couple of articles and abstracts in reputed journals and participate in many national and international scientific events.

Neurofibromatosis type 1 (NF1) is the most common genodermatosis. This autosomal dominant disease predisposes to the development of benign tumors (neurofibromas) but also malignant tumors. Soft tissue sarcomas (STS) are rare tumors characterized by great anatomic, histological and prognostic heterogeneity. Genetic predisposition participates in 3% of the STS and corresponds essentially to NF1. Some studies have tried to establish the link between STS and pregnancy, and have shown an increased risk of STS with late age at first pregnancy. We report the case of a 24-year-old patient with NF1 who developed a mass of the right flank during her first pregnancy, rapidly increasing in size, discovered in postpartum. Thoraco-abdominopelvic CT showed in the right flank a parietal mass of heterogeneous density infiltrating the inferior vena cava, with close contact with the ipsilateral iliac bone and no other lesions at a distance. An exeterization of the tumor was performed witch histological examination showed an undifferentiated sarcomatous process with muscle infiltration and invasion of the bone cortex. A post-operative radio-chemiotherapy is planned.rnFor this patient two questions are needed to be asked:rnIs this a sarcomatous transformation of plexiform, nodular neurofibromas, or a novo tumor?rnIs pregnancy considered us a risk factor for developing sarcomas? rnThis new observation supports the need for careful and regular monitoring, especially during pregnancy, of patients with NF1