14^thInternational Conference on Clinical and Experimental Dermatology June 19-20, 2017 Philadelphia ,USA

Biography:

De Rossi Fattaccioli is the member of American Academy of Dermatology, International Society of Peeling (ISP), Argentina Dermatology Society, Cilad Coligeo Iberolatino Mericano of Dermatology, Peruvian Society of Dermatology. He is the Principal Professor of Dermatology National University of Tacna “Jorge Basadre Grossman” and University of Tacna. He is an ex-President of Peruvian Society of Dermatology.

Abstract:

                    Chemical peeling                     is the most ancient procedure to remove and repair the photodamage effects (Ebers Papyrus). The newest with Erbium, Neodimiun YAG Carbon Dioxide (CO₂) Laser (ultrapulsed, fractional & others) are being used for the same i.e., remove sun damage elastotic collagen on reticular dermis, atrophic basal-malphigi stratum and hyperkeratosis cornium stratum and production of the best neo Collagen. Phenol deep chemical peelings (Backer-Gordon, Litton, Fintzi and Hetter formulas) have been used and still are being using extensively for facial skin rejuvenation. I introduce a “new” Personal Formulae (1986-2017) which use the heat like penetration factor and Glycerine like buffer and booster at the same time in this formula. These studies have been done to compare the effects of the treatments using histologic views in different periods of time. Biopsies of facial skin treated on pre and retroauricular zone were maked: 24 hours after the application of a new adaptation of the Baker´s formula: DeRossi Fattaccioli`s formulae for deep chemical peeling. Areas near the first biopsies were biopsied after 12 hours, 24 hours, 1 week, 2 weeks, 2 and 3 months after; and 24 hours, 48 hours, 72 hours, 1 week, 1 year and 10 years after application of De Rossi Fattaccioli`s Phenol-Croton. Initial biopsies showed deep chemical peeling Phenol-Croton oil DeRossi Fattacioli`s formulae, have produced a thick zone of new collagen formation, and at 3 months comparatively with others formulae of deep chemical peeling with De Rossi Fattaccioli´s formula show a thicker and wide new collagen zone.

Biography:

Michael Ibbott is an International Educator and Consultant. He has been in the Esthetic field for over 23 years, and has been trained and lectured in the US, Canada, Australia and Korea. His background in medical esthetics, electrology, Shiatsu therapy and other holistic modalities, have given him a unique perspective as to current trends and treatments available to those suffering from acne, rosacea, hyperpigmentation and melasma. He incorporates a logical progression in the understanding and the implementation of treatment protocols and patient care to advance concrete results.

Abstract:

This presentation focuses on the overview of acne and how to intervene and prevent this skin disorder. The lecture also focuses on: 1. Learning a different approach to treating acne. 2. Learning proper terminology to use with the clients and all the different treatment options that can be implemented in a medical spa setting. 3. Providing clients with optimum results. Lifestyle and prevention methods will be discussed. LED, IPL, new ionotherapy, supplements and all other treatment options will also be covered in this presentation.

Biography:

Shilpi Dhawan has vast experience in conduct of clinical research in various therapeutic areas . She completed her M.D in Pharmacology and  has passion in improving the health and wellbeing of the patients by bringing innovative ideas for increasing patient compliance , adherence to treatment  and safety of the patients. She believes in bringing quality and affordable medicines to the patients by doing quality research . She truly believes in generating the quality data and hence  trains the sites in protocol and GCP compliance .

Abstract:

Statement of the Problem: Topical retinoids such as Tretinoin are currently used as monotherapy and also in combination with clindamycin for treatment of acne.  Although the effectiveness of topical tretinoin is well established, yet the associated skin irritation is a limiting factor in some subjects due to the availability of drug to skin in high concentration in a short period. Novel tretinoin formulation incorporating microsphere technology may improve treatment tolerability, encourage adherence, and contribute to better long-term therapeutic outcomes. 

Purpose  was to evaluate efficacy, safety and tolerability of novel formulation of Tretinoin (Microsphere) 0.04% and Clindamycin 1% combination gel (T+C) versus Tretinoin 0.025% (T) and Clindamycin 1% (C) in the treatment of Acne vulgaris.

Methodology & Theoretical Orientation: Eligible male and female subjects ≥ 12 years in age with clinical diagnosis of moderate to severe facial acne vulgaris and willing to provide informed consent were randomized in 2:2:1 ratio [Tretinoin (microsphere) 0.04% and Clindamycin 1% combination gel(T+C): Tretinoin 0.025%(T): Clindamycin 1%(C)] and instructed to apply a pea-sized amount of the products to the entire face once daily at bedtime for 12 weeks. Efficacy was evaluated by assessing the reduction in count and severity of acne lesions at each visit. Local tolerability assessments were done at all follow-up visits.

 Findings: In our study, a statistically significant reduction in acne lesion count was observed with T+C compared to both T and C showing superior efficacy with combination. An early and a higher response rate in efficacy was observed in T+C arm compared to T and C arms. The combination was well tolerated in the study.

Conclusion & Significance:  The combination therapy of Tretinoin with microsphere technology and Clindamycin improved patient satisfaction and adherence to treatment by providing superior efficacy and faster onset of action with better tolerability

Biography:

Alexandre Malek is a Medical Doctor graduated in 2012, then he did Internal Medicine and now he is doing his last year of Infectious Disease Speciality. He  did his study at Saint Joseph University, Faculty of Médicine, Beirut, Lebanon. Currently he is doing one year of Infectious Disease in Paris, France. 

Abstract:

An 80 year-old Caucasian man was admitted to the hospital for prolonged fever, weight loss, and general status alteration. He noted a pruritic skin lesion. As past medical history, he had been treated for Hodgkin lymphoma in 1994 and Non Hodgkin lymphoma in 2004. One year ago, he developed Myelodysplastic Syndrome. Thoraco-abdominopelvic CT scan, gastroscopy and colonoscopy were normal. PPD skin test was negative and pancultures were sterile. The physical examination was normal except the presence of multiple, annular, rapidly growing erythematous plaques over the right thigh (Figure 1, 2). Bone marrow aspirate and biopsy revealed acute myeloblastic leukemia (AML). Diagnosis of Erythema Gyratum Repens (EGR) was made on clinical ground and it was secondary to AML. EGR in 80 % of cases is related to underlying malignancies most notably lung cancer. However, EGR in 20 % is associated with nonneoplastic diseases such as pulmonary tuberculosis, autoimmune or connective tissue conditions.

Biography:

Hemn Ahmed is an enthusiastic board certified Dermatologist. He searches for studying more degrees, which enables him to develop new skills, while strengthening those that he possesses. He started his vocation in Dermatology and Venereology and wants to get more experience and knowledge and enjoys being part of a successful and productive team. He has years of experience in research, evaluation, teaching and administration both in hospital and education institutions.

Abstract:

Statement of the Problem: Due to difficulties in obtaining skin scrapings from some patients and the lack of sensitivity of classical methods in diagnosis of scabies, dermatoscopy is commonly informative.

The Purpose of the Study: To evaluate the diagnostic accuracy of dermatoscopy for diagnosing scabies.

Methodology & Theoretical Orientation: A cross sectional study was carried out at Dermatology Center of Slemnai from 1^st June to end of October 2015 on 202 patients with clinical suspicion of scabies. The patients had confirmed diagnosis by clinical diagnosis, dermatoscopy and skin scrapping. 

Findings: Studying validity test of dermatoscopy in comparison to confirmed diagnosis revealed that the sensitivity of dermatoscopy was 91.5%, specificity 65%, and +ve predictive value 86%, -ve predictive value 76.5% and accuracy 83.6%. There was a significant association between positive dermatoscopy results and scabies patients with likely or very likely clinical diagnosis (p=<0.001).

Conclusion & Significance: Dermatoscopy is a good screening tool for scabies especially among high risk people.

Recommendations: Encouraging health directorates to start the use of dermatoscopy for screening of scabies, especially among refugees, displaced people and prisoners and the adoption of clinical diagnosis, skin scrapping and dermatoscopy as the diagnostic choice for scabies.

Biography:

Sevil Alan has received her PhD from Ege University, Turkey during the period of 1993-1999. She completed her Dermatology Residency at the Adana Numune Education and Research Hospital in Adana, Turkey. Currently, she is working as a Dermatologist in Akdeniz University School of Medicine, Turkey. She is an Editorial Board Member of journals like SM Dermatology, Dermatology & Pigmentation Disorders, and International Journal of Clinical Dermatology & Research (IJCDR). She is serving as a Reviewer for journals like JAMA Dermatology, International Research Journal of Public and Environmental Health, International Medical Journal of Sifa University. She has authored many research articles

Abstract:

GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15 is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.

Biography:

Kimberly Purdy Lloyd B.S. (pre-med) M.S. (Welch Scholar) utilizes her expertise in applied Biochemistry and Immunology to gain deeper understanding of how naturally derived ingredients may support health benefits. She collaborates and helps design protocols with scientific experts in basic and clinical research to understand functionality, safety and efficacy of novelty ingredients and product formulations. She is Executive Research and Development Scientist for LifePharm Inc., Lake Forest, CA, providing the liaison between academia and the company to bring quality scientific knowledge towards formulation and testing ingredients that may prove beneficial in cosmetic, medical device and dietary supplement formulations. She provides interpretation of scientific discoveries and studies for educational purposes for  consumers, health-care professionals and the business community to enhance their understanding of ingredient information, use and benefit when merited.   

Abstract:

Statement of the Problem: Fertilized avian egg extracts are used previously as a food supplement. However, their final composition and activity varied, due to chicken diet, egg incubation time, and final processing techniques. Here we report the pilot study on skin regenerative effects of the fertilized egg extract prepared from chickens fed with high quality grains (LifePharm Inc., Lake Forest, CA) and not exposed to any chemicals.

Methodology & Theoretical Orientation: The 0.5-1% solutions of this extract, prepared with our proprietary method and not exposed to heat, were added to primary cultures of dermal fibroblasts, isolated from skin biopsies derived from 6 healthy 24-43 year old women.  Then, the 3 and 7 day-old cultures, maintained in the presence and absence of our egg extract were assessed with quantitative immuno-fluorescence for their ability to proliferate, migrate and produce the new extracellular matrix (ECM), containing collagen, elastin and fibronectin, as previously described (Hinek A, et al. 2014).

Findings: Results showed that dermal fibroblasts incubated with 0.5-1% of the egg extract revealed a statistically significant up-regulation (60-70%) in their proliferation rate (immuno-detection of the Ki67-proliferative antigen), duplication of their migration abilities (cell culture scratch assay), as well as 2-4 times higher synthesis of fibronectin and deposition of the mature (cross-linked) elastin and collagen, as compared to untreated controls. Analysis of parallel cultures incubated with several specific inhibitors of biologically active factors that would positively modulate fibroblast proliferation and synthesis of major ECM components; revealed that our egg extract contained the active Platelet-Derived Growth factor (PDGF-BB), Transforming Growth Factor β-1 and a natural matrix cross-linker, Lysyl oxidase (LOX), but not metabolic steroid hormones or major kinases, which would potentially induce well known side effects and prohibit its use for tissue regeneration purposes.

Conclusion and Significance: In summary, we conclude that our egg extract does not induce any cytotoxic effects on the matrix-producing fibroblasts and that it’s described beneficial effects encourage its topical application for regeneration of the damaged skin and for the treatment of the hard-healing wounds.

Biography:

Kimberly Purdy Lloyd, BS (Pre-med), MS (Welch Scholar) utilizes her expertise in applied Biochemistry and Immunology to gain deeper understanding of how naturally derived ingredients may support health benefits. She collaborates and helps design protocols with scientific experts in basic and clinical research to understand functionality, safety and efficacy of novelty ingredients and product formulations. She is Executive Research and Development Scientist for LifePharm Inc., Lake Forest, CA, providing the liaison between academia and the company to bring quality scientific knowledge towards formulation and testing ingredients that may prove beneficial in cosmetic, medical device and dietary supplement formulations. She provides interpretation of scientific discoveries and studies for educational purposes for consumers, health-care professionals and the business community to enhance their understanding of ingredient information, use and benefit when merited.

Abstract:

Statement of the Problem: Fertilized avian egg extracts are used previously as a food supplement. However, their final composition and activity varied, due to chicken diet, egg incubation time, and final processing techniques. Here we report the pilot study on skin regenerative effects of the fertilized egg extract prepared from chickens fed with high quality grains (LifePharm Inc., Lake Forest, CA) and not exposed to any chemicals.

Methodology & Theoretical Orientation: The 0.5-1% solutions of this extract, prepared with our proprietary method and not exposed to heat, were added to primary cultures of dermal fibroblasts, isolated from skin biopsies derived from 6 healthy 24-43 year old women. Then, the 3 and 7 day-old cultures, maintained in the presence and absence of our egg extract were assessed with quantitative immuno-fluorescence for their ability to proliferate, migrate and produce the new extracellular matrix (ECM), containing collagen, elastin and fibronectin, as previously described.

Findings: Results showed that dermal fibroblasts incubated with 0.5-1% of the egg extract revealed a statistically significant up-regulation (60-70%) in their proliferation rate (immuno-detection of the Ki67-proliferative antigen), duplication of their migration abilities (cell culture scratch assay), as well as 2-4 times higher synthesis of fibronectin and deposition of the mature (cross-linked) elastin and collagen, as compared to untreated controls. Analysis of parallel cultures incubated with several specific inhibitors of biologically active factors that would positively modulate fibroblast proliferation and synthesis of major ECM components; revealed that our egg extract contained the active Platelet-Derived Growth factor (PDGF-BB), Transforming Growth Factor β-1 and a natural matrix cross-linker, Lysyl oxidase (LOX), but not metabolic steroid hormones or major kinases, which would potentially induce well known side effects and prohibit its use for tissue regeneration purposes.

Conclusion & Significance: In summary, we conclude that our egg extract does not induce any cytotoxic effects on the matrix-producing fibroblasts and that its described beneficial effects encourage its topical application for regeneration of the damaged skin and for the treatment of the hard-healing wounds.

Biography:

Abstract:

Hypertriglyceridemia with significant elevation in triglycerides are becoming increasingly common in American children who are obese and have sedentary lifestyle. But Genetic disorders, which cause hypertriglyceridemia in infants, are very rarely reported⁴. The latter defect can be induced by an abnormality either in the lipoprotein itself, Lipoprotein lipase deficiency or lipoprotein receptor defect.

Here we report a 6 weeks old female infant of Middle Eastern decent who presented with fever, cough and nasal congestion for 1 week. Physical examination was significant only for eruptive Xanthoma present around the right eyes. During blood draw for sepsis screen, patient noted to be having pink milky blood³. Baby was evaluated for sepsis and acquired causes for hyperlipidemia as the baby had Eruptive Xanthomas. Though the sepsis screen was not significant. The lipid profile was alarming with very high cholesterol of 975mg/dl (normal value: 120-200mg/dl) and triglycerides 1580mg/dl ( normal value: 40-150mg/dl), HDL 6mg/dl ( normal value 60-80mg/dl). Ophthalmology examination was significant for Lipemia Retinalis. Ultrasound abdomen done in view of pancreatitis due to hypertriglyceridemia was reported normal. EKG and Echo was also normal. Further evaluation of the parents and siblings revealed that the father and the older sister who is 6 years old also had pink milky blood with increase in cholesterol and triglycerides, which was undiagnosed.

Due to the presence of Infantile Xanthomas very high cholesterol, hypertriglyceridemia and familial presentation², Further evaluation of genetic causes for hyperlipidemia was done. Genetic analysis showed a T108R mutation in GPIHBPI gene suggestive of Chylomicronemia due to LPL deficiency⁵. Initially mother was advised exclusive breastfeeding with modification in her diet. This induced as sharp increase in triglycerides. Thus breastfeeding was discontinued. Baby was started on special formula with medium chain triglycerides oil. After 8 months, there has been a substantial decrease in the cholesterol to 145mg/dl and triglyceride to 812mg/dl without administering any lipid lowering medications. The Eruptive Xanthoma spontaneously resolved as the cholesterol and triglycerides showed decreasing trend. The child continues to closely follow with cardiologist, gastroenterologist and the lipid clinic as Chylomicronemia is associated with increased incidence of premature coronary vascular disease, pancreatitis and death. This case is being presented because of its uncommon presentation in infant. The use of lipid lowering medications in infants has not been studied because of rarity and hence much data is not available about treating familial hypercholesterolemia and hypertriglyceridemia in infants¹. The photos of the patient cannot be published, as parents did not consent for the photo due to religious reasons. Biopsy of the Cutaneous Xanthoma could not be performed due to cosmetic reasons as lesions were very near to the eyes. The photo of the milky blood is attached.

Biography:

Daniel de Rossi Fattaccioli is the member of the American Academy of dermatology , International Society of Peeling  ISP, Argentina Dermatology Society ,  Cilad  Coligeo Iberolatino Mericano of Dermatology , Peruvian Society of Dermatology. He is the Principal Professor of Dermatology National University of Tacna “Jorge basadre Grossman” and   particular university of Tacna. Ex President of Peruvian Society of  Dermatology.

Abstract:

Fotoaging`S treatment is the most popular in dermatology`S consult and is on constantly developing on innovation. We will show an old fashion treatment like depth deep chemical peeling ( 1903 Mc Kee First Publication ) but I will introduce on the congerence my experience with a new formule ( It’s A Baker&Gordonformule`S Variation ) and using heat ( 30-50*C Celsius Degrades) like a new strong penetration factor that produce more neocollagen that laser Co2 ultrapulsed.

Biography:

Anis Rahman is an acclaimed scientist in the field of nanotechnology. He is a winner of many scientific awards including NASA Nanotech Brief’s “Nano-50” award twice; CLEO/Laser Focus World’s “Innovation award.” Dr. Rahman is the founder of a terahertz company in Harrisburg, Pennsylvania . Dr. Rahman is a recognized scientific leader and member of professional organizations including the American Chemical Society (ACS), The Optical Society of America (senior member), and the SPIE. He is the current chair of the Small Chemical Businesses Division of the ACS (www.acs-schb.org). Dr. Rahman has been an author and co-author of more than 120 papers in peer reviewed journals and conference proceedings.

Abstract:

Terahertz multispectral reconstructive imaging is an effective tool for soft tissue imaging without any radiation damage [1–3] kike X-ray. Here, examples of biological tissue imaging are outlined to elucidate the technique. Reconstructive imaging utilizes the technique of rasterizing a specimen over a given area. ARP’s instrument allows the T-ray beam to be focused on a given layer under the surface; therefore, a 3D volume may be rasterized on a layer by layer basis. The reflected intensity is recorded preserving the exact coordinates over which measurements are done. The intensity matrix is then converted to image via inverse gridding algorithm [4, 5]. The algorithm is capable of accurate representation of the measured object similar to a charged couple device as has been explained previously [1, 2]. Here we present images of human skin under different diseased conditions as compared with healthy skin samples [1]. Fig. 1(a) exhibits terahertz reconstructive images of a healthy skin sample where regular cellular pattern is visible. This is expected from the healthy skin tissue. Fig. 1(b) shows an image of a skin sample diagnosed for basal cell carcinoma.  As evident from Fig. 1(b), diseased skin sample has lost its regular cellular pattern which are present for the healthy skin sample. This lack of systematic cellular structure may serve as an easy visual means to indicate that there is something wrong with the sample. As outlined in ref. [1], a combination of presence or absence of regular cellular structure, terahertz spectral comparison, and lack or presence or layering information is expected to serve as a fool proof diagnostic tool for different kind of skin cancers.

Biography:

Emily Shao graduated from the University of Queensland with a BSc/MBBS in 2015. She is currently working at the Royal Brisbane and Women’s Hospital as an intern and is completing a Masters of Public Health at the University of Sydney. An aspiring dermatologist, she is actively involved with dermatology-related research

Abstract:

Introduction: Panniculitis is an uncommon condition that typically presents as a non-specific area of erythema, with deep-seated nodules and plaques. There are a number of aetiologies the cause panniculitis, including infection, auto-immune, traumatic, and drug-induced. To our knowledge there has been no published cases of vancomycin-induced panniculitis.

Case Study: An 57-year-old Indigenous-Australian woman presented with a 1-month history of painful subcutaneous nodules. This coincided with commencement of vancomycin for treatment of bacteremia secondary to osteomyelitis. There were no other new medications started. On examination there were tender, firm subcutaneous nodules to the left anterior chest, bilateral flank, and back, with widespread eczematous plaques to the back. She reported a similar episode onset of development of a subcutaneous nodule 2 years ago, also after starting vancomycin. Histopathology showed eosinophilic panniculitis with dermal reaction containing frequent eosinophils. There was no histological support for either lupus or infective causes.

She had a complex medical background, including type two diabetes, obesity, chronic obstructive pulmonary disease, ischemic heart disease, dyslipidaemia, osteoarthritis, pseudoseizures, atrial fibrillation, rheumatic heart disease and subsequent infectious endocarditis, requiring a mitral valve replacement.

Discussion: This is the first case of panniculitis associated with vancomycin that we have found in the literature. Medications that have been associated with panniculitis include but is not limited to leukotriene modifying agents (1), interferon beta therapy (2), potassium bromide (3), protease inhibitors (4), glatiramir acetate(5, 6), and corticosteroid withdrawal (7).  

Conclusion: Panniculitis is associated with a wide range of aetiologies. Drug induced panniculitis and the mechanisms behind it are poorly understood, and features are often indistinguishable from other causes. In patients who present with panniculitis, clinicians should maintain a degree of suspicion for an adverse drug reaction, as there is a wide range of medications that can cause panniculitis.

Biography:

Silvia Cristina Jaramillo Manzur is currently studying the last year of the career of medical surgeon in Mexico. Her love for medicine began from my childhood because my father who is a surgeon always urged me to know more about this career. She would like to practice as a Dermatologist in the future, for what I have already done the first step since I passed the national exam of medical residences to perform a year of internal medicine and later dermatology. I have worked on several researches related to dermatology

Abstract:

We present a 47 year-old male with a six year history of a purulent ulcer at the parasternal region. Biopsy showed a granulomatous infiltrate with giant multinucleated cells and mycobacteria was cultured in Löwenstein-Jensen medium. PCR was positive for Mycobacterium tuberculosis. Mantoux test was 15 mm. Chest radiography showed right apical and basal reticular infiltrate. Culture was negative and no evidence of Acid-Fast Bacilli (AFB) on sputum and urine samples. HIV was no reactive. Improvement was observed after antituberculous therapy. The patient lost his social security; we could not undertake any clinical or epidemiological monitoring. Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis (3.5% of cutaneous tuberculosis). Its incidence has increased for the emergence of AIDS, use of immunosuppressive monoclonal antibodies but also by the emergence of multi-resistant strains, lack of interest in social control programs related to antituberculous, overcrowding, promiscuity and migration of people from endemic areas. Metastatic tuberculous abscess is the result of hematogenous dissemination, which can occur in immunocompromised or immunocompetent patients. It usually affects trunk and extremities with a "cold" abscess with secondary liquefaction, sinus tracts and ulcers. Lesions can multiple in military tuberculosis. Currently, diagnosis of tuberculosis should include culture and identification of species/complexes and drug sensitivity, after probability criteria such as: Tuberculoid granuloma with or without caseous necrosis; positive PPD or tuberculosis confirmed in another organ and a therapeutic trial with success after one week. Treatment includes a scheme of four drugs Rifampicin 150 mg, Isoniazid 75 mg, Pirazinamid 400 mg and Ethambutol 300 mg. Treatment should last for six months, as well as for treating patients co-infected with HIV, regardless of the stage of viral infection and patients should have treatment restarted when cultures and diagnostic testing persist with positive results.

Biography:

BB Mahajan is a Prof at Deptt. of Dermatology Venereology and Leprology at Government Medical College, Amritsar. He is the founder of Nail Society of India. He is also the Vice President of IADVL since 2016. He was the Organising secretary of Dermazone 2001, Cuticon 2006 (Asr), Cuticon 2012 (Fdk) and VII MCV (Asr). His area of interest include Psoriasis, Vitiligo, STDs, nail disorders.

Abstract:

Premature greying is the term used when hair turns grey prematurely. Though greying of hair is a natural process, yet in the modern era of cosmetological revolution, it has assumed a lot of aesthetic relevance, especially premature hair greying. Black, thick and shiny hair is not only sign of youthfulness and good health, but is also cosmetically appealing. Caucasian people will begin to gray in their mid-thirties, African-American people can retain their original hair color until their mid-forties, Asian people begin graying in their late thirties, whereas, as compared to South Indian population, North Indians begin to grey in their early thirties. Countless products are flooding the market everyday like, hair oils, shampoos, conditioners, gels and hair dyes which claim to slow/revert premature hair greying, but all these provide only temporary relief, if any. Before understanding the greying on hair, its etiopathogenesis is very important. There are various known causes of premature hair greying like excessive prolonged stress, thyroid deficiencies, excessive intake of tea, coffee and alcohol, fried foods, spices, sour and acidic foods, deficiency of nutrients, especially, copper reduces melanin production, deficiency of B₁₂ & biotin and hereditary causes. Common hair oils used in India include Coconut oil, Amla oil (Indian Gooseberry), Mustard oil, Olive oil, Almond oil and Mineral oils, out of which Coconut oil is the most commonly used one. Coconut oil massage not only improves the blood circulation of the scalp but also gradually restores hair color & prevents further greying of hair, and thus, delays the greying process and strengthens the hair and promotes growth. Coconut oil additionally, has soothing and cooling properties. Coconut oil is owing to its low molecular weight and high affinity for hair proteins, having the capacity to penetrate the cuticle and displacing the air which has replaced the melanin. It may have a role in not only delaying the premature greying of hair, but also giving cosmetic acceptability to the hair by making them appear less grey.

Biography:

Sukesh Sukumaran completed his Pediatric Residency from UMDNJ, Camden, NJ and Pediatric rheumatology Fellowship from USC in Los Angeles, CA. He completed his Medical school 21 years ago from University of Kerala, Trivandrum, India. He is currently an Assistant Professor of Pediatric Rheumatology at UAMS/ACH. He was the Program Director for the pediatric rheumatology fellowship program at University of Florida prior to the current position.

Abstract:

Rheumatic diseases have a wide variety of cutaneous manifestations especially in the pediatric population. The dermatologic manifestations may be the sole features in some of the rheumatic diseases especially at the initial presentation. The common rheumatic diseases include the pediatric systemic lupus erythematosus, juvenile dermatomyositis, systemic onset juvenile idiopathic arthritis, juvenile scleroderma and juvenile psoriasis.  Dermatological manifestations are also seen with less common rheumatic diseases including the periodic fever syndrome, SAPHO syndromes, Neutrophilic dermatoses and pediatric vasculitis. The timely recognition of these rashes helps to diagnose the underlying rheumatic disease and also to start appropriate immune modulation. With the new biological management of the rheumatic disease the challenges are higher as initiation of the appropriate treatment within the therapeutic window will help to alleviate the long term damage to the joints or internal organs. The biologics commonly used in pediatric rheumatology includes different anti TNF agents (etanercept, adalimumab, infliximab), anti IL1 (anakinra, canakinumab, rilanocept), anti IL6- tocilizumab, anti B cell treatment with rituximab and belimumab, co stimulatory inhibitors like abatacept, anti IL12/23 agent and IL17 agent like secukinumab. The medications used to treat different rheumatic conditions lead to dermatological manifestations and implicated in the new onset of cutaneous lupus and drug induced lupus. The topic is very important as the field of rheumatology and dermatology is changing its face every day with the advent of new biologic medications. In this talk we are focusing on the rheumatic diseases with cutaneous manifestations and new biologic medications.

Biography:

Sarath N Bodapati graduated from James Cook University with MBBS (hons) in 2014. He currently works at Royal Brisbane and Women’s Hospital as a Resident Medical Officer. As an aspiring dermatologist, he is interested in medical dermatology, and is actively involved with research.

Abstract:

Introduction: Sneddon’s syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa (LRC). The cerebrovascular manifestations of SS are most often due to ischemia, including transient ischemic attacks and cerebrovascular accidents (CVA).

Case: A 39-year-old women presented for routine follow-up of a net-like cyanotic discolouration over her posterior thighs and lower back. The rash had been present for 15+ years, and had previously been diagnosed as idiopathic livedo reticularis (LR). On further questioning, it was revealed that the patient had a CVA at the age of 17, assumed to be secondary to amphetamine use. As such, repeat biopsies were performed, and a diagnosis of LRC was confirmed. This lead to an eventual diagnosis of idiopathic SS.

Discussion: The distinction between LRC and LR is relatively new concept. LR is a benign, primary disorder that affects young to middle-aged females while LRC is a secondary disorder. LRC is similar to LR in appearance, but it differs in its location (more generalized and widespread), its shape (irregular, broken, circular segments), and persistence despite warmth.

Conclusion: Pathophysiology of SS is not completely understood. SS likely stems from a number of acquired or congenital hemostatic abnormalities, which preferentially involve cerebral and cutaneous vascular beds. Any patient suspected of SS should undergo various blood tests (e.g. thrombotic screen), skin biopsy, and thorough cardiovascular evaluation (e.g. MRI head).

Biography:

Abstract:

Biography:

Justin D Nabity has been a Financial & Career Development Advisor to physicians since 2005. He is a Board Member of the Entrepreneurs Organization (EO) and National Association of Insurance and Financial Advisors (NAIFA). He is listed on 2014 Best Financial Advisers for Medical Economics, 2013 Million Dollar Round Table’s Top of the Table, and is a repeat invited speaker for American Association of Ophthalmologists (AAO) as well as the Mayo Fellowship Association (MFA). He has authored dozens of lectures on contract review, financial planning, disability insurance, physician job search, debt management, retirement planning and wealth planning, among others.

Abstract:

Financial preparedness is not just about investing in the right funds; it’s about finding the right job and negotiating well. It’s about tackling debt aggressively, including student loans, while not neglecting retirement planning. For residents and fellows, it’s about creatively and purposefully putting a limited pay-check to work instead of waiting until finally finishing training. It’s also about being prepared for job interviews and protecting a physician’s potential with the right coverage. According to the 2015 MGMA Compensation Report, the median annual earning potential of a dermatologist is *$350,000. This earning potential illustrates the compelling reason why when planning for retirement; proper diversification goes far beyond having an investment allocation spread out among various asset classes. A truly diversified investment strategy also takes into consideration the impact of taxes both today and when retirement is reached. A diversified investment strategy provides physicians the ability to minimize tax liability in order to optimize the tax efficiency of their portfolio both today and in retirement years. Traditionally, individuals rely solely on their 401(k), IRAs or other tax-deferred vehicles for savings. However, this one-dimensional savings strategy provides little to no flexibility when an individual reaches retirement. Diversification involves spreading investments among tax-deferred, tax-favored and taxable accounts during a physician’s working years so they can plan to optimize their tax situation in retirement. Whether discussing contract negotiation, interviewing, debt management or retirement planning, the remedy to this concerning statistic is to universally “Plan for the End in the Beginning.”

Biography:

Sevil Alan has received her PhD from Ege University, Turkey during the period of 1993-1999. She completed her Dermatology Residency at the Adana Numune Education and Research Hospital in Adana, Turkey. Currently, she is working as a Dermatologist in Akdeniz University School of Medicine, Turkey. She is a editorial board member of journals like SM Dermatology, Dermatology & Pigmentation Disorders, and International Journal of Clinical Dermatology & Research (IJCDR). She is serving as a Reviewer for journals like JAMA Dermatology, International Research Journal of Public and Environmental Health, International Medical Journal of Sifa University. She has authored many research articles.

Abstract:

GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15 is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.

Biography:

Anzhela Grevtseva has graduated in 2011 from Stavropol State Medical Academy, Ministry of Health and Social Development of the Russian Federation with specialty in Pediatrics. She has completed Post-graduation in Dermatovenereology from Russian Medical Academy of Postgraduate Education, Ministry of Health of Russian Federation, Department of dermatovenereology, micology and cosmetology in 2011-2013. Currently, she is a PhD student in Russian Medical Academy of Postgraduate Education Ministry of Health of Russian Federation, Department of dermatovenereology and cosmetology, with scientific specialty in Skin and venereological diseases. Her scientific research is focused on clinical and pathogenical characteristics of acne and rosacea complicated demodecosis. She has published more than 10 papers in journals.

Abstract:

Background: Demodex-mites live in sebaceous or meibomian glands and hair follicles. Demodex is possible to detect by scraping, at extraction of ducts contents of sebaceous glands or remove the eyelashes and/or eyebrows; standardized skin surface biopsy (SSSB); skin biopsy with the subsequent histology of the received samples; dermatoscopy; skin biopsy with histological analysis. In medicine there will always be a demand for informative, high-tech and non-invasive diagnostic methods. These methods include confocal laser scanning in vivo microscopy (CLSM).

Aim: To compare the efficiency of diagnostics of demodecosis for patients with acne and rosacea by various methods.

Materials & Methods: We observed 60 patients with acne and rosacea complicated demodecosis (group I), 60 patients with acne and rosacea without demodecosis (group II) and 30 healthy volunteers (group III).

Results: On the CLSM the mite was found in all patients with demodecosis. Demodex was defined as rounded or long cone-shaped formations in the hair follicle orifices and sebaceous glands. During the inspection of patients from group II, it was succeeded to identify mites at 10 (13%) patients at whom the method of scraping was shown by negative result. At study of healthy volunteers from group III, the method of the CLSM found Demodex mites in follicles in 6 people (8%).

Conclusion: As a result of the research of patients with acne, rosacea and healthy volunteers, there was an established high informational content of the CLSM in diagnostics of a demodecosis and its advantage over usual light microscopy.

Biography:

Hani Sheikh Alshabab is an Syrian Histopathologist graduated from Damascus University in 2003, then he traveled to USA where he achieved my ECFMG certificate, meanwhile he participated in Genomic research related to the genetic role in coronary artery stents stenosis and obesity at Geisinger Health System located in Danville at the beautiful state of  Pennsylvania, then he  moved back to Syria where he enrolled in Anatomic Pathology residency program at Ministry of Health, graduated in 2010, and in 2012 I obtained The Arab Board Certificate/The Fellow Of Arab Board Of Health Specialization Of Pathology (ABHS-Path), with almost 6 years experience in pathology distributed between The General Assembly of Damascus Hospital, private practice, southern Iraq government hospital and finally Aster Hospital in the amazing city of Dubai, UAE. He is a member of Syrian Society of Pathology and Emirates Pathology Society, and have attended many conferences during my career including The Arab Health, Medlab 2016 held in Dubai UAE 2016, Emirates Surgical Pathology Conference held in Dubai UAE 2015, The 23^rd Congress of the Arab Division, International Academy of Pathology held in Beirut- Lebanon 2011, and The 12^th Meeting of the Syrian Society of Pathology held in Damascus, Syria, 2010 in collaboration with the University of Texas, MD Anderson Cancer Center, Houston

Abstract:

• One person dies of melanoma every hour (every 52 minutes). An estimated 76,380 new cases of invasive melanoma were diagnosed in the U.S. in 2016.  An estimated 10,130 people died of melanoma in 2016. 
• Melanoma accounts for less than one percent of skin cancer cases, but the vast majority of skin cancer deaths.  
• The vast majority of melanomas are caused by the sun. In fact, one study found that about 86 percent of melanomas can be attributed to exposure to ultraviolet (UV) radiation from the sun. Regular daily use of an SPF 15 or higher sunscreen reduces the risk of developing melanoma by 50 percent.
• Naevus number and size established as a heritable factor and a melanoma risk factor.

• Frequent & consistent chromosomal aberrations with comparative genomic hybridization.
• Deletions of chromosomes 9p (82%), 10q (63%), and 6q (28%).
• Genetic differences based on anatomic location and sun exposure. Acral melanomas have more aberrations of chromosomes 5p, 11q, 12q, and 15. Lentigo maligna melanomas show more frequent loss of 17p & 13q.
• BRAF^V600E mutations are frequent in melanocytic naevi, implicating BRAF^V600E as an initiating mutation during the evolution of melanoma.
• Mutations occur during the evolution of melanoma from precursor lesions, and there is an intermediate phase of progression between a naevus and a melanoma.
• Studies indicating the 18 genetic loci that confer susceptibility to melanoma.
• UV radiation could generate BRAF^V600E mutations which induce a senescence-like state in melanocytes.

• Early users of cytogenetic testing technologies in cutaneous pathology are more likely to be younger, affiliated with an academic institution and fellowship trained or board certified in dermatopathology.