Day 1 :
Brigham & Women’s Hospital
Time : 10:05-10:35
Martin C Mihm graduated “Summa cum laude” from Duquesne University in 1955. He obtained his medical degree from the University of Pittsburgh Medical Center in 1961. He specialized in Internal Medicine, Dermatology, Pathology, and Dermatopathology. He started residency in dermatology at the Massachusetts General Hospital (MGH) in 1964 and after completing pathology residency joined the staff in 1973. In 1976, he founded one of the first five residency training programs in Dermatopathology in the United States. He became a Professor at Harvard Medical School in 1980. He joined the faculty of Albany Medical Center in 1993 to establish a dermatology and dermatopathology training program. In 1996, he returned to MGH to continue work in melanoma and to establish a vascular malformation clinic as Clinical Professor. On July 1, 2010, he assumed the position as Director of the Melanoma Program in Dermatology at the Brigham and Women’s Hospital and Associate Director Dana-Farber and Brigham and Women’s Cancer Center. He holds now five adjunct professorships at different schools in the United States. He also was a co-founder of the Rare Tumor Institute of the WHO in Milan, Italy and acted as external coordinator for five years. He is currently co-director of the EORTC melanoma pathology program. He has written over four hundred articles and authored and co-authored twelve books. His research interests have principally been related to malignant melanoma, the study of delayed hypersensitivity reactions in animals and humans with Dr. Harold Dvorak, and more recently has begun to investigate the pathogenesis of vascular anomalies. He began his melanoma studies with Dr. Wallace Clark in 1965 and coauthored the first publication of the classification of malignant melanoma into subtypes.
This presentation will review the clinical and pathologic features of the Spitz group of lesions that cause both clinical and histopathological difficulties in diagnosis. The clinical features of each entity will be described, followed by the appropriate histopathologic criteria that will also be illustrated. The benign Spitz nevus will be compared to atypical Spitz nevi, and atypical Spitz’s tumors. Many of the latter lesions have the ability to metastasize but usually do not extend beyond regional lymph nodes. The criteria for the diagnosis of the atypical Spitz’s tumor will be presented in detail. The malignant counterpart of the Spitz nevus will also be described. The treatment of each entity will be presented. A recently described entity, considered by many a variant of the Spitz nevus, the so-called BAPoma, will also be shown in clinical and histopathologic detail. The mutation that results in this tumor will be discussed, as well as the heritable nature of patients affected by this trait. Finally, the second portion of the talk will review malignant melanoma of childhood, its incidence, clinical presentation, and histopathology. Emphasis will be placed on the lesions that have the capacity to cause death in children. These lesions will be compared to and contrasted with the Spitz nevus and its associated atypical counterparts. Treatment of childhood melanoma will also be detailed. Recent molecular techniques including Frozen In-Situ Hybridization (FISH) will also be reviewed.
Founder of Cockerell Dermatopathology
Keynote: Cutaneous melanoma
Time : 10:35-11:05
Clay J. Cockerell, MD is Clinical Professor of Dermatology and Pathology at the University of Texas Southwestern Medical Center and Director of the Division of Dermatopathology. He is the President and Owner of Cockerell Dermatopathology and the past Medical Director of Cockerell and Associates Dermatopathology as well as a diplomat of the American Academy of Dermatology and American Board of Dermatopathology. Dr. Cockerell is internationally recognized for his contributions to both dermatology and dermatopathology. He is the past president of the American Academy of Dermatology. For many years, Dr. Cockerell has overseen an educational program designed to train the next generation of dermatopathologists. He has served as Associate Editor of the Journal of the American Academy of Dermatology and is on the editorial boards of a number of medical journals including the American Journal of Dermatopathology.
This talk presents an overview and update of what’s new in the diagnosis and treatment of Melanoma. Topics include the epidemiology, primary prevention, diagnosis, and treatment of melanoma. Emphasis placed on clinicohistopathologic correlation and novel genetic testing that can guide diagnosis, prognosis and treatment