Autoimmune skin disorders cause challenging clinical issues that have yet to be studied. Hemidesmosomes (HDs) are the crucial structural proteins in the skin (Fig. 1).\r\nREFERENCES:\r\n1- Alireza Nasoori et al., MAGGOT THERAPY BY OPEN PACK METHOD…, Alireza Nasoori et al., J Nurs Care 2016, 5:4 (Suppl)\r\n2- Sherman, Ronald A. “Mechanisms of maggot-induced wound healing …†Evidence-Based Complementary and Alternative Medicine 2014.\r\n3- Proksch et al., Exp Dermatol. 2008 Dec;17 (12):1063-72.\r\n4- Chaudhari PR, Vaidya MM, Histol Histopathol. 2015 Apr;30(4):425-34.\r\n5- Nishie, Wataru. Journal of dermatological science 73, no. 3 (2014): 179-186.\r\nWhen HDs are compromised by immune system, severe skin lesions such as epidermolysis bullosa simplex and bullous pemphigoid can occur. These lesions are usually controlled by immunosuppressive and anti-inflammatory treatments. However, the blisters which remain by the disease should be protected against infection and biofilms. Traditional medicine may open up ways for such cases. In this respect, maggot therapy [the use of larvae of Lucilia sericata] has provided satisfactory outcomes for wound treatment due to debridement of the biofilm, and improvement of regeneration. The extract [secretion and excretion] of the maggots has antimicrobial, anti-inflammatory and tissue regenerative properties. Thus, in-vivo and in-vitro investigations of the efficacy of maggots’ extract for management of autoimmune blistering disorders are worth consideration.\r\n
